Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and\r\nmaintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the\r\ngut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina\r\npropria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the\r\nimmune defense and changes in their secretion in intestinal inflammatory diseases and cancer.
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